IN VITRO SYSTEMS

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CelTox Sampler

MedTec Biolab, Inc. has developed a new line of in vitro exposure systems to satisfy the demand for in vitro toxicity testing. Our superior in vitro exposure systems simplify the process for conducting exposure of cells at the air-liquid interface. These systems were design with the user in mind by providing a versatile design, small foot-print, and effective delivery of airborne contaminants to cultured cells. Our first system, the CelTox Sampler, will be commercially available in 2019. Contact us to learn more!

Applications

The CelTox Sampler can be a useful tool for various applications such as:

  • Combustion Emissions
    • Diesel & Biodiesel Exhaust
    • Biomass Burning
    • Wildfires
  • Cigarette & E-cigarette Smoke
  • Volatile Chemicals
  • Secondary Organic Aerosols
  • Bioaerosols
  • Nanomaterials
  • Dermal Exposures
  • Drug Delivery

Literature & Talks

  • The predecessor to the CelTox Sampler was named the Gillings Sampler. The manuscript "The Gillings Sampler – An electrostatic air sampler as an alternative method for aerosol in vitroexposure studies" can be found here.
  • The CelTox Sampler's unique temperature and humidity regulation is critical to avoid cytotoxicity due to cell desiccation. The manuscript "Regulating temperature and relative humidity in air–liquid interface in vitrosystems eliminates cytotoxicity resulting from control air exposures" can be found here.
  • In 2018,  a symposium entitled "In VitroTest Methods to Model Local Respiratory Effects after Exposure to Pulmonary Toxicants: Not Just Smoke and Mirrors" was held at the Society of Toxicology Annual Meeting. Here, a talk entitled "Understanding Air-Liquid Interface Cell Exposure Systems: A Comprehensive Assessment of Various Systems under Identical Conditions" was presented. Data in this talk clearly demonstrates the superior performance of the Gillings Sampler (the predecessor prototype of the CelTox Sampler). A manuscript on this study is in preparation. This talk can be found here.

Background

The vision and concept of the CelTox Sampler originated at the University of North Carolina at Chapel Hill. Dr. Jose Zavala developed what is now the CelTox Sampler during his graduate studies at UNC-Chapel Hill under the direction of Drs. Harvey Jeffries, Ken Sexton, and Will Vizuete. This technology captured media attention in 2013 when National Public Radio published a story on this system. The article can be found here and you can listen to the story next.

Audio Title

A short cartoon was developed by NPR summarizing the vision and concept of the CelTox Sampler. Enjoy!

Interested in air-liquid interface exposures?

Jose Zavala, Ph.D.

For more information contact Jose directly via email, Linkedin or send us a message via the site.
[email protected]

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